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2,5,6-trisubstituted pyridines as novel, highly potent and selective cb2 agonists for the prevention of organ damage
Stefanie Bendels1, Caterina Bissantz1, Jürgen Fingerle1, Uwe Grether*1, Sabine Grüner1, Paul Hebeisen1, Atsushi Kimbara1, Qingping Liu0,2, Matthias Nettekoven1, Marco Prunotto1, Mark Rogers-Evans1, Stephan Röver1, Franz Schuler1, Tanja Schulz-Gasch1, Christoph Ullmer1, Zhiwei Wang0,2, Wulun Yang0,2
1F. Hoffmann-La Roche Ltd., Switzerland, 2BioDuro, China
Poster sessions - all posters to be displayed throughout:  Cardiovascular
5-HT1A Receptors Mediate the Motor Effects of the Non-Psychotropic Phytocannabinoid Cannabidiol
Francisco Espejo-Porras*1, Javier Fernández-Ruiz1, Roger G. Pertwee2, Raphael Mechoulam3, Concepción García1
1Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, and CIBERNED and IRYCIS, Spain, 2School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, UK, 3Department od Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Israel
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
A hydrolysis-resistant fluorescent endocannabinoid analogue to investigate cellular endocannabinoid uptake and trafficking
Andrea Chicca*1, Simon Nicolussi1, Silvia Ortega Gutierrez2, Jürg Gertsch1
1Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland, 2Universidad Computense Madrid, Spain
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
A versatile fluorescent activity assay for endocannabinoid hydrolases
Dina Navia-Paldanius*, Juha Savinainen, Jarmo Laitinen
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Finland
Poster sessions - all posters to be displayed throughout:  Cell Fate
Activation Of Endocannabinoid System In Human Myocardial Hypertrophy
Georg D. Duerr*1, Jan C. Heinemann1, Silke Dunkel1, Andreas Zimmer2, Beat Lutz3, Raissa Lerner3, Wilhelm Roell1, Friedrich Mellert1, Chris Probst1, Bahman Esmailzadeh1, Armin Welz1, Oliver Dewald1
1Department of Cardiac Surgery, University Clinical Center Bonn, Germany, 2Institute of Molecular Psychiatry, Life & Brain Center, University of Bonn, Germany, 3Institute of Physiological Chemistry, University Medical Center Mainz, Germany
19 April - Oral Communications:  Cardiovascular  -  17:15-18:00
17:30-17:45
Alterations In The Endocannabinoid System In The Valproic Acid Rat Model Of Autism
Daniel M Kerr1,3, Lisa Downey1, Michelle Conboy1, David P Finn2,3, Michelle Roche*1,3
1Physiology, National University of Ireland Galway, Ireland, 2Pharmacology and Therapeutics, National University of Ireland Galway, Ireland, 3NCBES Centre for Pain Research and Galway Neuroscience Centre, National University of Ireland Galway, Ireland
Poster sessions - all posters to be displayed throughout:  Brain Function
An Investigation Into The Effects Of Cannabinoids On Neurotrophin Expression In The Rat Brain
Jack Prenderville*, Veronica Campbell, Áine Kelly
Trinity College, Ireland
19 April - Oral Communications:  Neuroinflammation  -  10:00-10:30
10:00-10:15
Anti-inflammatory And Analgesic Effects Of Endocannabinoids In A Mouse Model Of Acute Arthritis
Jason McDougall, Eugene Krustev*, Allison Reid
Dalhousie University, Canada
19 April - Oral Communications:  Neuroinflammation  -  10:00-10:30
10:15-10:30
Anti-inflammatory And Anti-pruritic Effects Of WO20100083-440, A Novel, Potent Inhibitor Of FAAH In A Murine Model Of Atopic Dermatitis
Michael Soeberdt*1, Simon Nicolussi2, Ulrich Knie1, Jürg Gertsch2, Christoph Abels1
1Dr. August Wolff GmbH & Co. KG Arzneimittel, Germany, 2Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland
Poster sessions - all posters to be displayed throughout:  Neuroinflammation
Antithrombotic Effect of Rimonabant – Selective CB1 Cannabinoid Receptor Antagonist  in Experimental Models of Thrombosis
Agnieszka Zakrzeska*, Piotr Szoka, Anna Muszynska, Tomasz Gredzinski, Wioletta Kisiel, Ewa Chabielska
Medical University of Bialystok, Poland
Poster sessions - all posters to be displayed throughout:  Cardiovascular
Beta Amyloid mediated blockade of Long Term Potentiation in the CA1 region of mouse hippocampal slices is partially attenuated by Cannabidiol
Blathnaid Hughes*, Darren Walsh, Eoin Minnock, Caroline Herron
University College Dublin, Ireland
Poster sessions - all posters to be displayed throughout:  Neuroinflammation
Bilateral Microinjection Of The CB1 Receptor Agonist ACEA Into The PAG Differentially Modulates Formalin-evoked Nociceptive Behaviour In Sprague-Dawley And Stress Hyper-responsive Wistar-Kyoto Rats
Elaine Jennings*1,3, Kieran Rea1,3, Bright Okine1,3, Fiona McGowan1,3, Michelle Roche2,3, David Finn1,3
1Pharmacology and Therapeutics, School of Medicine, Ireland, 2Physiology, School of Medicine, Ireland, 3NCBES Centre for Pain Research and Neuroscience Cluster, Ireland
Poster sessions - all posters to be displayed throughout:  Pain
Blockade of Endocannabinoid System as a New Target for the Cognitive Impairment of Fragile X Syndrome
Arnau Busquets-Garcia*1, Maria Gomis-González1, Thomas Guegan1, Carmen Agustín-Pavón2, Mara Dierssen2,3, Rafael Maldonado1, Andres Ozaita1
1Departament de Ciències Experimentals i de la Salut. Universitat Pompeu Fabra, Spain, 2Centre for Genomic Regulation (CRG), 4, Spain, 3Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Spain
19 April - Oral Communications:  Brain Function  -  15:45-16:15
16:00-16:15
Cannabidiol (CBD) Priming Enhances Cisplatin Killing Of Cancer Cells
Aine B Henley*, Alistair V Nunn, Gary S Frost, Jimmy D Bell
Imperial College London, UK
Poster sessions - all posters to be displayed throughout:  Cell Fate
Cannabidiol Protects An In Vitro Model Of The Blood-Brain Barrier Against Increased Permeability Following Oxygen-Glucose Deprivation
William Hind*, Timothy England, Saoirse O'Sullivan
University of Nottingham, UK
19 April - Oral Communications:  Cardiovascular  -  17:15-18:00
17:45-18:00
Cannabinoid 1 (CB1) receptor involvement in the development of endometriosis in mice.
Paola Panina-Bordignon*1, Ana Maria Sanchez1, Francesca De Michele1, Paola Viganò1, Javier Diaz2, Guillermo Velasco2, Massimo Candiani3
1San Raffaele Scientific Institute, Italy, 2Universitad Complutense, Spain, 3Vita-Salute San Raffaele University, Italy
20 April - Oral Communications:  Cell Fate  -  10:00-10:45
10:15-10:30
Cannabinoid CB1 receptor functions and endocannabinoid levels in the progression of normal aging
Anne Legler*, Raissa Lerner, Laura Bindila, Beat Lutz, Krisztina Monory
University Medical Center of the Johannes Gutenberg University, Germany
Poster sessions - all posters to be displayed throughout:  Brain Function
Cannabinoid Receptor Expression in Human Osteoarthritic Cartilage
Sara Dunn*1, J Mark Wilkinson2, Aileen Crawford3, Christine L Le Maitre1, Rowena AD Bunning1
1Biomedical Research Centre, Sheffield Hallam University, UK, 2Academic Unit of Bone Metabolism, Department of Human Metabolism, University of Sheffield, UK, 3Centre for Biomaterials & Tissue Engineering, University of Sheffield, School of Clinical Dentistry, UK
20 April - Oral Communications:  Hot Topics  -  11:15-12:30
11:45-12:00
Cannabinoid Receptors in Human and Rat (Wistar and Zucker) Skeletal Muscle
Fairouz Shermado*, kostas Tsintzas, Bennett Andrew
University of Nottingham, UK
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Cannabinoid signalling and IL-1β are critical mediators regulating omega-3 PUFAs neural stem cell fate decisions
Harpreet Kaur Mandhair*, Rachel Elizabeth Ann Fincham, Jolanta Opacka-Juffry, Simon Dyall, Francisco Molina-Holgado
University of Roehampton, UK
Poster sessions - all posters to be displayed throughout:  Cell Fate
Cannabinoids and experimental stroke: a systematic review and meta-analysis
Nadiah Abd Rasid, William Hind*, Saoirse O'Sullivan, Tim England
University of Nottingham, UK
Poster sessions - all posters to be displayed throughout:  Brain Function
CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate
Carmen La Porta*1, Andreea Bura1, Auxiliadora Aracil-Fernández2, Jorge Manzanares2, Rafael Maldonado1
1Laboratori de Neurofarmacologia, Facultat de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Spain, 2Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Spain
Poster sessions - all posters to be displayed throughout:  Pain
CB1 and CB2 gene expression in atopic and non-atopic asthma - expression levels before and after treatment with inhaled corticosteroids or leukotriene receptor antagonist
Carina Kozmus*1,2, Vojko Berce3, Uros Potocnik1,4
1Centre for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Slovenia, 2Institute for Molecular and Cell Biology, University of Porto, Portugal, 3Department of Pediatrics, University Medical Centre Maribor, Slovenia, 4Laboratory for Biochemistry Molecular Biology and Genomics, Faculty for Chemistry and Chemical Engineering, University of Maribor, Slovenia
Poster sessions - all posters to be displayed throughout:  Neuroinflammation
CB1 Receptor Modulates Social Investigation in Mice
Ana Luisa Terzian*1,2, Vincenzo Micale3, Carsten T. Wotjak0
1Max-Planck Institute of Psychiatry, Germany, 2Graduate School of Systemic Neuroscience / LMU, Germany, 3CEITEC (Central European Institute of Technology) Masaryk University, Czech Republic
19 April - Oral Communications:  Brain Function  -  15:45-16:15
15:45-16:00
CB1 Receptors In The Paraventricular Nucleus Of The Hypothalamus Elicit Central Sympathoexcitation
Barbara Malinowska*1, Emilia Grzeda1, Eberhard Schlicker2
1Dept. Exp. Physiol. Pathophysiol. Med. Univ., Poland, 22Dept. Pharmacol. Toxicol., Univ. Bonn, Germany
Poster sessions - all posters to be displayed throughout:  Cardiovascular
CB2 Receptor Activation is Anti-Inflammatory in an Endotoxin-Induced Uveitis Model
J. Thomas Tougri*1, Anna-Maria Szczesniak1, Juan Zhou0,1, Christian Lehmann1, Melanie Kelly1
1Dalhousie University Department of Phamacology, Canada, 2Dalhousie University Department of Anesthesia, Canada
20 April - Oral Communications:  Hot Topics  -  11:15-12:30
12:15-12:30
Cell cycle regulation by sn-1 diacylglycerol lipase (DAGL) in neural stem cells
Francisco Molina-Holgado*1, Eduardo Molina-Holgado2
1University of Roehampton, UK, 2Laboratory of Neuroinflammation, Unidad de Neurologia Experimental, Hospital Nacional de Parapléjicos (SESCAM), Spain
20 April - Oral Communications:  Cell Fate  -  10:00-10:45
10:30-10:45
Changes in endocannabinoids and endocannabinoid-like molecules level in the selected rat brain structures in cocaine relapse.
Beata Bystrowska*1, Irena Smaga1, Ewa Nowak0,2, Małgorzata Filip1,2
1Department of Toxicology, Faculty of Pharmacy, Jagiellonian University, Medical College, Poland, 2Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Poland
Poster sessions - all posters to be displayed throughout:  Brain Function
Chromenopyrazole as Versatile Cannabinoid Scaffold: from CB1 towards CB2 Selectivity
Paula Morales*1, Maria Gómez-Cañas2, Dow P. Hurst3, Moisés Garcia-Arencibia2, Javier Fernández-Ruiz2, Patricia Reggio3, Pilar Goya1, Nadine Jagerovic1
1Consejo Superior de Investigaciones Científicas, Instituto de Química Médica, Spain, 2Facultad de Medicina, Universidad Complutense de Madrid, Departamento de Bioquímica y Biología Molecular. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Ins, Spain, 3Department of Chemistry and Biochemistry, University of North Carolina Greensboro, USA
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Delta9-Tetrahydrocannabinol Mediated Memory Deficits Involve Protein Kinase C Gamma Signalling
Maria Gomis-González*, Arnau Busquets-Garcia, Emma Puighermanal, Rafael Maldonado, Andrés Ozaita
Laboratori de Neurofarmacologia. Departament de Ciències Experimentals i de la Salut. Universitat Pompeu Fabra, Spain
Poster sessions - all posters to be displayed throughout:  Brain Function
Does a 28 Day Exposure To The Fatty Acid Amide Hydrolase Inhibitor, URB597 Prevent Age-Related Dysregulation Of The Lysosomal System And Accompanying Neurodegeneration Within The Male Wistar Rat Brain?
Aoife Gowran*1, Janis Noonan1, Riffat Tanveer1, Marina Lynch1,2, Veronica Campbell1
1Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, University of Dublin, Trinity College, Ireland, 2Discipline of Physiology, School of Medicine, Trinity College Institute of Neuroscience, University of Dublin, Trinity College, Ireland
Poster sessions - all posters to be displayed throughout:  Cell Fate
Effect of synthetic cannabinoids added to smoked herbal mixtures on GABAergic and glutamatergic synaptic transmission in mouse brain slices
Bela Szabo*, Eszter Boros, Mario Lederer
Department of Pharmacology; Albert-Ludwigs-Universität, Germany
Poster sessions - all posters to be displayed throughout:  Brain Function
Effects of acute and repeated administration of escitalopram and FAAH inhibitor on the level of endocannabinoids and endocannabinoid-like molecules in different rat brain structures
Irena Smaga*1, Beata Bystrowska1, Irmina Turek1, Małgorzata Filip1,2
1Department of Toxicology, Faculty of Pharmacy, Jagiellonian University, Medical College, Poland, 2Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Poland
Poster sessions - all posters to be displayed throughout:  Brain Function
Enhanced social interaction skills in CB1 receptor knockout mice
Miriam Schneider*1, Andreas Zimmer2
1RG Developmental Neuropsychopharmacology, CIMH, Germany, 2Institute of Molecular Psychiatry, University of Bonn, Germany
20 April - Oral Communications:  Hot Topics  -  11:15-12:30
11:15-11:30
Gender differences in the anxiolytic action of benzodiazepines: role of CB1 and GABAA receptors
Leyre Urigüen*1, Carolina Muguruza1, Auxiliadora Aracil-Fernández2, Luis F Callado1, Jorge Manzanarez2
1Department of Pharmacology, University of the Basque Country UPV/EHU , CIBERSAM and Biocruces Health Research Institute, Spain, 22Instituto de Neurociencias/Universidad Miguel Hernández CSIC/UMH, Spain
Poster sessions - all posters to be displayed throughout:  Brain Function
Human osteoblast (HOB) proliferation and differentiation in vitro is affected by a range of novel endocannabinoids.
Kate Hadley-Brown, Susan Anderson*, Marie Smith, Saoirse O'Sullivan
University of Nottingham, UK
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Investigating The Role Of Medial Prefrontal Cortex PPARα Signalling In Formalin-Evoked Nociceptive Responding In Rats
Bright Okine*1,3, Kieran Rea1,3, Joseph Price1, Weredeselam Olango1,3, Michelle Roche2,3, David Finn1,3
1Pharmacology & Therapeutics, School of Medicine,NUI, Ireland, 2Physiology, School of Medicine, NUI, Ireland, 3Neuroscience Cluster and Centre for Pain Research, NCBES, NUI, Ireland
Poster sessions - all posters to be displayed throughout:  Pain
Investigating The Role Of The Putative Cannabinoid Receptor GPR55 in Vascular Control in Mice
Eilidh McNaughton*, Vanessa Ho
St. George's University of London, UK
19 April - Oral Communications:  Cardiovascular  -  17:15-18:00
17:15-17:30
Investigation On The Involvement Of Reactive Oxygen Species And Mitogen-Activated Protein Kinase In Endothelium-Dependent Relaxation In Spontaneously Hypertensive Rats
Billy Kong, Godfrey Man, Susan Leung*
The University of Hong Kong, Hong Kong
Poster sessions - all posters to be displayed throughout:  Cardiovascular
Mechanisms Underlying The Cerebellar Deficits Produced By Repeated Cannabis Exposure
Laura Cutando*1, Arnau Busquets-Garcia1, Emma Puighermanal1, Maria Gomis-González1, José María Delgado-García2, Agnès Gruart2, Rafael Maldonado1, Andrés Ozaita1
1Laboratori de Neurofarmacologia. Facultat de Ciéncies de la Salut i de la Vida. Universitat Pompeu Fabra, Spain, 2División de Neurociencias, Universidad Pablo de Olavide, Spain
Poster sessions - all posters to be displayed throughout:  Neuroinflammation
Neonatal Maternal Deprivation And A High Fat Diet Induce Sex-Dependent Effects On Endocannabinoid Levels In Three Different Types Of Adipose Tissues
Vincenzo Di Marzo1, Fabiana Piscitelli1, Virginia Mela2, Alvaro Llorente-Berzal*2, Julie Chowen3,4, Maria Paz Viveros2
1Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Italy, 2Departamento de Fisiologia (Fisiología Animal II), Facultad de Biología, Universidad Complutense and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Spain, 3Department of Pediatrics, Universidad Autónoma de Madrid, Spain, 4CIBER de Fisiopatología de Obesidad y Nutrición, Instituto Carlos III, Spain
Poster sessions - all posters to be displayed throughout:  Brain Function
Nicotine-Conditioned Place Preference Requires the Cannabinoid CB2 Receptor
Bogna M. Ignatowska-Jankowska*, Pretal P. Muldoon, Aron H. Lichtman, M. Imad Damaj
Virginia Commonwealth University, USA
18 April - Oral Communications:  Novel Receptor Targets  -  16:30-17:00
16:30-16:45
Novel n-3 Fatty Acid Derived N-Acyl Ethanolamides: a Potential Link Between n-3 Fatty Acids and Inflammation
Michiel Balvers*, Jocelijn Meijerink, Mieke Poland, Noortje Creemers, Renger Witkamp
Wageningen University, The Netherlands
Poster sessions - all posters to be displayed throughout:  Pain
Pepcan localization and potential role in the rodent central nervous system
Stefanie Hofer*1, William Ralvenius2, Hanns Ulrich Zeilhofer2, Jürg Gertsch1
1Institue of Biochemistry and Molecular Medicine, University of Bern, Switzerland, 2Institute of Pharmacology and Toxicology, University of Zürich, Switzerland
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Pharmacological Characterisation Of A Binding Site For Leelamine
William Devane*, David Finn
National University of Ireland, Galway, Ireland
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Phosphorylation of Juxtamembrane C-terminal of  CB1 Cannabinoid Receptor in NT18TG2 Cells
Khalil Eldeeb*1, Sudha M. Cowsik2, Allyn C. Howlett1
1Wake Forest University, USA, 2Jawaharlal Nehru University, India
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Phytocannabinoids Modulate Mitochondrial Dynamics in Cell Lines; Stress Adaptation
Alistair Nunn*, Aine Henley, Leigh Brody, Jimmy Bell
Imperial College, UK
18 April - Oral Communications:  Novel Receptor Targets  -  16:30-17:00
16:45-17:00
Piperazine and Piperidine Triazole Ureas as Ultrapotent and Highly Selective Inhibitors of Monoacylglycerol Lipase
Niina Aaltonen1,2, Juha Savinainen*2, Casandra Riera Ribas1,2, Jani Rönkkö1,2, Anne Kuusisto1, Jani Korhonen1, Dina Navia-Paldanius1,2, Jukka Häyrinen2, Piia Takabe2, Heikki Käsnänen1, Tatu Pantsar1, Tuomo Laitinen1, Marko Lehtonen1, Sanna Pasonen-Seppänen2, Antti Poso1, Tapio Nevalainen1, Jarmo Laitinen2
1School of Pharmacy, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Finland, 2School of Medicine, Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Finland
Poster sessions - all posters to be displayed throughout:  Neuroinflammation
PLASMA MEMBRANE AND INTRACELLULAR CB1 RECEPTORS MODULATE PROLIFERATION AND MIGRATION OF OLIGODENDROCYTE PROGENITOR CELLS
M Alejandra Sanchez-Rodriguez1, Oscar Gomez1, MQ Uyen Le1, Concepcion Sanchez-Caro1, Francisco Molina-Holgado2, Eduardo Molina-Holgado*1
1Laboratorio de Neuroinflamacion, Hospital Nacional de Paraplejicos, Spain, 2Department of Life Sciences, Health Sciences Research Centre, University of Roehampton, UK
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Pyrazole-Type Cannabinoid Ligands Conjugated With Fluoro-deoxy-carbohydrates As Potential PET-Imaging Agents: Synthesis And CB1/CB2 Receptor Affinity Evaluation
Simona Frau*1, Sergio Dall'Angelo1, Gemma L. Baillie1, Ruth A. Ross1, Marilena Pira2, Paolo Lazzari2, Matteo Zanda1
1Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, UK, 2Neuroscienze PharmaNess Scarl, Parco Scientifico della Sardegna, Italy
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Quantification of endocannabinoids in postmortem brain of subjects with Major Depression
Carolina Muguruza*1, Marko Lehtonen2, Niina Aaltonen2, Benito Morentin3, J Javier Meana1,4, Luis F Callado1,4
1Department of Pharmacology, University of the Basque Country UPV/EHU and Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain, 2School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Finland, 3Section of Forensic Pathology, Basque Institute of Legal Medicine, Spain, 4Biocruces Health Research Institute, Spain
20 April - Oral Communications:  Hot Topics  -  11:15-12:30
11:30-11:45
Rimonabant Multiple Ligands Targeting CB and PPAR Receptors
Nieves Fresno*1, Ruth Pérez-Fernández1, Manuel Macías-González2,3, José Elguero1, Juan Decara3,4, María Gómez-Cañas5, Moisés García-Arencibia5, Javier Fernandez-Ruiz5, Fernando Rodríguez de Fonseca3,4, Pilar Goya1
1Instituto de Química Médica, IQM-CSIC, Spain, 2Servicio de Endocrinología Nutrición, Hospital Virgen de la Victoria (Fundación IMABIS), CIBER Fisiopatología de la Obesidad y Nutrición. CB06/03, Instituto de Salud Carlos III, Spain, 3Fundación Hospital Carlos Haya, Spain, 4CIBER OBN (Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Spain, 5Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense de Madrid; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED); Ins, Spain
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Role of Cannabinoid System in the Enhanced Antinociceptive Effects of the Combination of Indomethacin with Minocycline Against Paclitaxel-induced Neuropathic Pain
Subramanian Parvathy, Willias Masocha*
Kuwait University, Kuwait
19 April - Oral Communications:  Pain  -  12:30-12:45
12:30-12:45
Role Of  Endocannabinoid  System  During   Neuronal  Development In vitro
Mónica Tapia*1,2, Carmen Guaza1, Juan José Garrido2
1Instituto Cajal, Functional and Systems Neurobiology department, Spain, 2Intituto Cajal, Molecular, Cellular and Developmental Neurobiology department, Spain
Poster sessions - all posters to be displayed throughout:  Brain Function
Role Of Endothelial Mechanisms In Anandamide-Evoked Vasorelaxant Effects In Human Pulmonary Arteries
Marta Baranowska-Kuczko*, Hanna Kozlowska, Monika Kloza, Miroslaw Kozlowski, Barbara Malinowska
Medical University of Bialystok, Poland
Poster sessions - all posters to be displayed throughout:  Cardiovascular
Role of the CB2 Cannabinoid Receptor in ERBB2-Driven Breast Cancer Progression
Eduardo Pérez-Gómez1, Clara Andradas1, María Muñóz Caffarel1,2, Gema Moreno Bueno3, Juana María Flores4, Sandra Blasco-Benito*1, Manuel Guzmán1, Cristina Sánchez1
1Dept. Biochemistry and Molecular Biology I, School of Biology, Complutense Universit, Spain, 2Department of Pathology, University of Cambridge, UK, 3Dept. Biochemistry, Autonoma University, Spain, 4Dept. Animal Surgery and Medicine, School of Veterinary, Complutense University, Spain
20 April - Oral Communications:  Cell Fate  -  10:00-10:45
10:00-10:15
Role of the Transient Receptor Potential Vanilloid-type2 Agonist Cannabidiol in Multiple Mieloma
Maria Beatrice Morelli1, Massimo Offidani3, Giancarlo Discepoli4, Matteo Santoni5, Consuelo Amantini1, Valerio Farfariello0,6, Sonia Liberati2, Pietro Leoni3, Giorgio Santoni1, Massimo Nabissi*1
1School of Pharmacy, Section of Experimental Medicine, University of Camerino, Italy, 2Dept Molecular Medicine, Sapienza University, Italy, 3Clinic of Haematology, Azienda Ospedaliero-Universitaria Ospedali Riuniti Ancona, Italy, 4Centre of Genetic Medicine and Prenatal Diagnosis, Az.Osp, G.Salesi, Italy, 5Dept of Clinic Oncology, Polytechnic University of Marche, Italy, 6Dept of Urology and Andrology, University of Perugia, Italy
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Selective CB2 agonist RO6839328 protects mouse kidneys from acute injury
Jürgen Fingerle*1, Sabine Grüner1, Christian M Apfel1, Christoph Ullmer1, Jürgen Funk3, Ivan Formentini1, Atsushi Kimbara2, Mark Roger-Evens2, Stephan Röver2, Matthias Nettekoven2, Franz Schuler3, Giorgio Ottaviani3, Stefanie Bendels2, Uwe Grether2
1F.Hoffmann-La Roche Ltd, Pharma Research & Early development, Discovery Biology, Grenzacherstr. 124, Switzerland, 2F.Hoffmann-La Roche Ltd, Pharma Research & Early development, Medicinal Chemistry, Grenzacherstr. 124, Switzerland, 3F.Hoffmann-La Roche Ltd, Pharma Research & Early development, Nonclinical Safety, Grenzacherstr. 124, Switzerland
20 April - Oral Communications:  Hot Topics  -  11:15-12:30
12:00-12:15
Sex Dependent Long-Term Effects Of Adolescent Exposure To THC And/Or MDMA On Glial Reactivity And Serotoninergic And Cannabinoid Systems In Rats: An Immunohistochemical Study
Alvaro Llorente-Berzal*1, Ana Belén López-Rodríguez1, Luis Miguel Garcia-Segura2, Maria Paz Viveros1
1Depto. Fisiología (Fisiología Animal II), Fac Biología, Univ. Complutense, Spain, 2Instituto Cajal, Consejo Superior de Investigaciones Cientificas (CSIC), Spain
Poster sessions - all posters to be displayed throughout:  Brain Function
Spinal Endocannabinoid/Endovanilloid System As A Target For Suppression Of Neuropathic Pain In Rats
Natalia Kolosowska*, Wioletta Makuch, Barbara Przewlocka, Katarzyna Starowicz-Bubak
Institute of Pharmacology Polish Academy of Sciences, Poland
Poster sessions - all posters to be displayed throughout:  Pain
Study of Trpv1, Trpv2 and Trpa1 channels activation by cannabidiol (CBD) and cannabivarine (CBDV) in whole-cell patch clamp analysis
Fabio Arturo Iannotti*1, Camille Soubrane2, Vincenzo Di Marzo1, Gary Stephens0
1National Council of Research (CNR), Institute of Biomecular Chemestry (ICB), Italy, 2School of Pharmacy, University of Reading, UK
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
Systemic Or Central Inhibition Of Fatty Acid Amide Hydrolase Attenuates The Expression Of Inflammatory Mediators In Discrete Brain Regions Following Systemic Immune Challenge
Rebecca Henry*1,3, Daniel Kerr1,2, David P Finn2,3, Michelle Roche1,3
1Physiology, School of Medicine, National University of Ireland, Galway, Ireland, 2Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland, 3NCBES Centre for Pain Research and Neuroscience Cluster, National University of Ireland, Galway, Ireland
Poster sessions - all posters to be displayed throughout:  Neuroinflammation
THCV effectively decrease lipid levels in various biological systems and has insulin sensitizing effects in hepatocytes
Cristoforo Silvestri*, Andrea Martella, Vincenzo Di Marzo
Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Italy
Poster sessions - all posters to be displayed throughout:  Cardiovascular
The 11-hydroxy Metabolite Of Δ9-Tetrahydrocannabivarin Behaves As An Apparent CB1 and CB2 Receptor Neutral Antagonist
Maria Grazia Cascio*, Pietro Marini, Daniele Bolognini, Roger G. Pertwee
University of Aberdeen, UK
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
The anti proliferative effect of n-3 fatty acids and n-3 n-acylethanolamines in breast cancer cells is mediated through cannabinoid receptors and fatty acid amide hydrolase
Jisun Lee*, Klaus Wahle, Maria Cascio, Roger Pertwee, Steven Heys, Iain Brown
Aberdeen University, UK
Poster sessions - all posters to be displayed throughout:  Cell Fate
The CB1 Cannabinoid Receptor Drives Dorsal Telencephalic Progenitor Expansion by Regulating Pax6 and Tbr2 Transcription Factor Expression: Involvement of mTORC1
Javier Díaz-Alonso1,2, Tania Aguado1,2, Adán de Salas*1,2, Zaira Ortega1,2, Inmaculada de Prada3, María Ángeles Pérez-Jiménez3, Beat Lutz4, Manuel Guzmán1,2, Ismael Galve-Roperh1,2
1Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain, 2Department of Biochemistry and Molecular Biology I, School of Biology, Instituto de Investigación Sanitaria Ramón y Cajal (IRYCIS) and Instituto Universitario de Investigaciones Neuroquímicas (IUIN), , Spain, 3Hospital Infantil Universitario Niño Jesús, Spain, 4Institute of Physiological Chemistry, Medical Center of the Johannes Gutenberg University Mainz, Germany
Poster sessions - all posters to be displayed throughout:  Brain Function
The Combined Effects Of 2-Arachidonoylglycerol And Leptin On Human Osteoblasts In Vitro
Marie Smith*, Saoirse O'Sullivan, Susan Anderson
Department of Vascular Medicine, School of Graduate Entry Medicine and Health, University of Nottingham, UK
Poster sessions - all posters to be displayed throughout:  Cardiovascular
The Effect Of Intra-striatal Injection Of The Inflammagen, Lipopolysaccharide, On Expression Of The Cannabinoid Type-2 (CB2) Receptor In The Rat Brain
Ruth Concannon*, Bright Okine, David Finn, Eilis Dowd
National University of Ireland, Galway, Ireland
Poster sessions - all posters to be displayed throughout:  Neuroinflammation
The Effects Of Anandamide And Leptin On Human Osteoblasts In Vitro
Marie Smith*, Saoirse O'Sullivan, Susan Anderson
Department of Vascular Medicine, School of Graduate Entry Medicine and Health, University of Nottingham, UK
Poster sessions - all posters to be displayed throughout:  Cardiovascular
The Effects Of Anandamide (And Other Endocannabinoids) On Permeability In A Cell Culture Model Of The Blood-Brain Barrier
William Hind*, Timothy England, Saoirse O'Sullivan
University of Nottingham, UK
Poster sessions - all posters to be displayed throughout:  Cardiovascular
The endocannabinoid system modulates stress-induced hyperalgesia in mice
Ermelinda Lomazzo*, Laura Bindila, Raissa Lerner, Claudia Schwitter, Beat Lutz
University Medical Center of the Johannes Gutenberg University, Institute of Physiological Chemistry, Germany
Poster sessions - all posters to be displayed throughout:  Pain
The endocannabinoid-like mediator DHEA (docosahexaenoylethanolamide) modulates COX-2 activity
JOCELIJN MEIJERINK*, MIEKE POLAND, MICHIEL BALVERS, RENGER WITKAMP
HUMAN NUTRITION/NUTRITION AND PHARMACOLOGY, The Netherlands
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
The Pharmacological Effects Of Palmitoylethanolamide (PEA) On Intestinal Permeability In Vitro Using Caco-2 Cell
Mustafa Karwad*, Jonathan Lund, Mike Larvin, Saoirse O'Sullivan
University of Nottingham, UK
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms
The Role Of CB1 Receptors In The RVM In Mediating The Antinociceptive Effects Of The FAAH Inhibitor URB597 In Wistar-Kyoto Rats
Kieran Rea*, Weredeselam Olango, Bright Okine, Kathleen Coyle, Brendan Harhen, Michelle Roche, David Finn
National University of Ireland, Galway, Ireland
Poster sessions - all posters to be displayed throughout:  Pain
The Vasorelaxant Effects of Anandamide in the Human Mesenteric Artery 
Christopher Stanley*, Saoirse O'Sullivan
University of Nottingham, UK
Poster sessions - all posters to be displayed throughout:  Cardiovascular
TRANSIENT RECEPTOR POTENCIAL VANILLOID SUBTYPE 1 (TRPV1) IN ALZHEIMER DISEASE AND THE EFFECTS OF CANNABINOIDS
Diana Aguirre-Rueda*, Soraya Vallés
University of Valencia, Spain
Poster sessions - all posters to be displayed throughout:  Brain Function
TRPV1 mRNA Expression Within The CNS Of Two Rat Strains Differing In Nociceptive Responsivity
Manish K. Madasu*1,3, Bright Okine1,3, Weredeselam M. Olango1,3, Michelle Roche2,3, David P. Finn1,3
1Pharmacology and Therapeutics, School of Medicine, NUI, Ireland, 2Physiology, School of Medicine, NUI, Ireland, 3Neuroscience Cluster and Centre for Pain Research, NCBES, NUI, Ireland
Poster sessions - all posters to be displayed throughout:  Pain
TRPV1 Receptor Phosphorylation Determines The Development Of Neuropathic Pain In Rat CCI Model
Natalia Malek*1, Michal Korostynski0,2, Barbara Przewlocka1, Katarzyna Starowicz1
1Department of Pharmacology of Pain, Institute of Pharmacology, Polish Academy of Science, Poland, 2Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Science, Poland
Poster sessions - all posters to be displayed throughout:  Pain
Voluntary alcohol intake and CB1-receptor density in outbred Wistar rats
Shima Momeni*, Lena Bergström, Erika Roman
Uppsala University, Sweden
Poster sessions - all posters to be displayed throughout:  Brain Function
WOBE437 - Prototype of a novel class of potent, selective endocannabinoid reuptake inhibitors
Simon Nicolussi*1, Andrea Chicca1, Michael Soeberdt2, Christoph Abels2, Juan Manuel Viveros Paredes3, Alejandro Aparisi Rey4, Beat Lutz4, Jürg Gertsch1
1Institute of Biochemistry and Molecular Medicine, University of Berne, Switzerland, 2Dr.August Wolff Arzneimitte, Germany, 3Institute of Immunopharmacology, University of Guadalajara, Mexico, 4Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Germany
Poster sessions - all posters to be displayed throughout:  Novel Receptor Targets and Mechanisms